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- Title
Inhibitory effect of cranberry polyphenol on biofilm formation and cysteine proteases of Porphyromonas gingivalis.
- Authors
Yamanaka, A.; Kouchi, T.; Kasai, K.; Kato, T.; Ishihara, K.; Okuda, K.
- Abstract
Background and Objective: The purpose of this study was to investigate the effects of cranberry polyphenol fraction on biofilm formation and activities of Arg-gingipain and Lys-gingipain in Porphyromonas gingivalis. Material and Methods: The polyphenol fraction was prepared by using a glass column packed with Amberlite XAD 7HP and 70% aqueous ethanol as an elution solvent. Results: Synergistic biofilm formation by P. gingivalis and Fusobacterium nucleatum was significantly inhibited by the polyphenol fraction at a concentration of 250 µg/mL compared with untreated controls ( p < 0.01). Arg-gingipain and Lys-gingipain activities in P. gingivalis ATCC 33277 and FDC 381 were inhibited significantly at a polyphenol fraction concentration of ≥ 1 µg/mL ( p < 0.05). Conclusion: These findings indicate that the polyphenol fraction inhibits biofilm formation and the Arg-gingipain and Lys-gingipain activities of P. gingivalis.
- Subjects
CRANBERRIES; POLYPHENOLS; BIOFILMS; CYSTEINE proteinases; PORPHYROMONAS gingivalis; FUSOBACTERIUM; PERIODONTITIS; ENZYMES
- Publication
Journal of Periodontal Research, 2007, Vol 42, Issue 6, p589
- ISSN
0022-3484
- Publication type
Article
- DOI
10.1111/j.1600-0765.2007.00982.x