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- Title
Microglía y neurodegeneración en el núcleo talámico dorsomedial de la rata infante después del Estado Epiléptico.
- Authors
Adoniram, García-Martínez; Fernando, Quiroz-Vergara; Iván, Véliz-Castillo; Mariely, Álvarez-Croda; María-Leonor, López-Meraz
- Abstract
Introduction: Status epilepticus (SE) produces extensive neuronal death in the developing brain. Among the affected brain structures, neuronal degeneration is most prominent in the central and lateral segments of the mediodorsal nucleus of the thalamus. On the other hand, microglia is a specialized system of cellular immunity that is activated or over-expressed when there is damage to brain tissue. Aim: The goal of this study was to determine the extent and the time course of microglia activation and neuronal injury in the mediodorsal thalamic nucleus after SE induced in fourteen-days-old rat pups. Method: SE was induced with the lithium-pilocarpine model. Presence of microglia with nonactivated and activated morphology was determined in the mediodorsal thalamic nucleus by immunohistochemical methods, in control conditions and 2, 6, 24 and 48 h following SE and correlated to the appearance of neuronal injury detected by Fluoro-Jade C (F-JC) staining. Results: Activated microglial and neuronal injury was detected in the mediodorsal thalamus 6-48 h following SE, while no changes in total microglia were observed. *Conclusion: These data demonstrate that in the mediodorsal thalamic nucleus, microglia is activated in response to seizures and that this activation may contribute to SE-induced neuronal injury in the immature brain.
- Subjects
MICROGLIA; NEURODEGENERATION; THALAMIC nuclei; RISK factors of neurodegeneration; ANIMAL experimentation; IMMUNOHISTOCHEMISTRY; NEUROGLIA; RATS; STAINS &; staining (Microscopy); THALAMUS; STATUS epilepticus; DISEASE complications
- Publication
Archivos de Neurociencias, 2018, Vol 23, Issue 4, p6
- ISSN
1028-5938
- Publication type
Article