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- Title
The effects of vitamin D, fish oil and exercise on cardiovascular parameters in ovariectomized rats.
- Authors
Hazar, Hale Uyar; Hazar, Fatih; Büyüköztürk Karul, Aslıhan; Demirci, Buket
- Abstract
This study compared effects of vitamin D, fish oil and exercise on cardiovascular parameters in ovariectomized rats. This is an experimental study conducted with 45 female Wistar Albino rats; consisted of one sham (n=8) and four intervention (n=37) groups. Rats (n=37) were oophorectomized and, randomly divided into four groups at the end of the first week following wound healing. Interventions were applied to the groups of oophorectomize+Dvit, oophorectomize+fish oil and oophorectomize+exercise for 12 weeks. In analyzing the data, ANOVA and Tamhane's T2 tests were used (p<0.05). The levels of total-cholesterol (66.7 ± 7.6 mg/dL), HDL-cholesterol (33.8 ± 2.1 mg/dL), TOS (7.3 ± 1.2 μmol H2O2 Eq/L), TAS (4.0 ± 0.5 mmol Trolox Eq/L), OSI (0.2 ± 0.1) and total-cholesterol/HDL-cholesterol (2.0 ± 0.3) were obtained significant in exercising oophorectomized rats according to the oophorectomized rats (p<0.05). The estrogen levels of rats using vitamin D and fish oil and exercising were found to be higher than those in menopause. It was concluded that exercising oophorectomized rats had a lower risk of cardiovascular disease. In this context, exercise/physical activity should be recommended and must be supported for practicing in order to protect the cardiovascular health of postmenopausal women.
- Subjects
FISH oils; RATS; LABORATORY rats; CARDIOVASCULAR diseases risk factors; CARDIOVASCULAR diseases; POSTMENOPAUSE; CARDIOVASCULAR fitness; VITAMIN D
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2021, Vol 46, Issue 5, p517
- ISSN
0250-4685
- Publication type
Article
- DOI
10.1515/tjb-2021-0185