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- Title
Toward the Total Synthesis of Klaivanolide: Complete Reinterpretation of Its Originally Assigned Structure.
- Authors
Ferrié, Laurent; Ferhi, Sabrina; Bernadat, Guillaume; Figadère, Bruno
- Abstract
Klaivanolide is an antiparasitic natural product isolated from Uvaria klaineana, whose structure was originally assigned as a seven-membered lactone ring. Attempts towards the total synthesis of klaivanolide led us to revise its original structural assignment based on both experimental evidence and spectroscopic data. The isolated compound was revealed to be a known molecule, acetylmelodorinol, originally isolated from Melodorum fruticosum. Vibrational circular dichroism simulation of the reassigned structure was also performed to reinvestigate our previous studies on the determination of the absolute configuration of klaivanolide.
- Subjects
ANTIPARASITIC agents; NATURAL products; LACTONES; ORGANIC cyclic compounds; CHEMICAL reactions
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 28, p6183
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201402741