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- Title
Access to Cyclic α-CF<sub>3</sub>-Substituted α-Amino Acid Derivatives by Ring-Closing Metathesis of Functionalized 1,7-Enynes.
- Authors
Mailyan, Artur K.; Krylov, Ivan M.; Bruneau, Christian; Dixneuf, Pierre H.; Osipov, Sergey N.
- Abstract
An efficient method for the preparation of new α-CF3 α-amino acid 1,7-enynes that contain electron-donating and electron-withdrawing groups on the triple bond has been developed that proceeds through a Sonogashira-type coupling reaction. The ring-closing enyne methathesis (RCEYM) of the obtained 1,7-enynes with commercially available Grubbs and Hoveyda catalysts provides access to a series of new cyclic α-amino acids. The latter compounds that contain the 1,3-diene moiety are attractive building blocks for the construction of trifluoromethylated polycyclic systems.
- Subjects
ORGANIC acids; PARTICLES (Nuclear physics); CONSTRUCTION contracts; CHEMICAL inhibitors; AMINO acids; CATALYSTS
- Publication
European Journal of Organic Chemistry, 2013, Vol 2013, Issue 24, p5353
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201300619