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- Title
Serum ionized calcium in dogs with chronic renal failure and metabolic acidosis.
- Authors
Kogika, Marcia M.; Lustoza, Marcio D.; Notomi, Marcia K.; Wirthl, Vera A. B. F.; Mirandola, Regina M. S.; Hagiwara, Mitika K.
- Abstract
Chronic renal failure (CRF) is a common disease in dogs, and many metabolic disorders can be observed, including metabolic acidosis and calcium and phosphorus disturbances. Acidosis may change the ionized calcium (i-Ca) fraction, usually increasing its concentration. In this study we evaluated the influence of acidosis on the serum concentration of i-Ca in dogs with CRF and metabolic acidosis. Dogs were studied in 2 groups: group I (control group = 40 clinically normal dogs) and group II (25 dogs with CRF and metabolic acidosis). Serum i-Ca was measured by an ion-selective electrode method; other biochemical analytes were measured using routine methods. The i-Ca concentration was significantly lower in dogs in group II than in group I; 56% of the dogs in group II were hypocalcemic. Hypocalcemia was observed in only 8% of dogs in group II when based on total calcium (t-Ca) concentration. No correlation between pH and i-Ca concentration was observed. A slight but significant correlation was detected between i-Ca and serum phosphorus concentration ( r=−.284; P= .022), as well as between serum t-Ca and i-Ca concentration ( r= .497; P < .0001). The i-Ca concentration in dogs with CRF and metabolic acidosis varied widely from that of t-Ca, showing the importance of determining the biologically active form of calcium. Metabolic acidosis did not influence the increase in i-Ca concentration, so other factors besides acidosis in CRF might alter the i-Ca fraction, such as hyperphosphatemia and other compounds that may form complexes with calcium.
- Publication
Veterinary Clinical Pathology, 2006, Vol 35, Issue 4, p441
- ISSN
0275-6382
- Publication type
Article
- DOI
10.1111/j.1939-165X.2006.tb00161.x