We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Controlled Human Infection Model for Hepatitis C Virus Vaccine Development: Is It Time to Be Real?
- Authors
Liang, T Jake; Feld, Jordan J; Shoukry, Naglaa H; Thomas, David L
- Abstract
The article offers information on the challenges in developing a Hepatitis C virus (HCV) vaccine, highlighting the need for a controlled human infection model (CHIM) to accelerate vaccine development. Topics include the recent phase 2 trial of a T-cell-based HCV vaccine candidate, the potential benefits of CHIM in de-risking vaccine candidates, and the ethical considerations surrounding CHIM testing.
- Subjects
VACCINES; CLINICAL trials; HUMAN research subjects; VIRAL hepatitis; HEPATITIS C; VACCINE development; VACCINE effectiveness; INFECTION control
- Publication
Clinical Infectious Diseases, 2023, Vol 77, pS215
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciad343