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- Title
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity.
- Authors
Pollett, Simon D; Richard, Stephanie A; Fries, Anthony C; Simons, Mark P; Mende, Katrin; Lalani, Tahaniyat; Lee, Tida; Chi, Sharon; Mody, Rupal; Madar, Cristian; Ganesan, Anuradha; Larson, Derek T; Colombo, Christopher J; Colombo, Rhonda; Samuels, Emily C; Broder, Christopher C; Laing, Eric D; Smith, Darci R; Tribble, David; Agan, Brian K
- Abstract
Little is known about severe acute respiratory syndrome coronavirus 2 "vaccine-breakthrough" infections (VBIs). Here we characterize 24 VBIs in predominantly young healthy persons. While none required hospitalization, a proportion endorsed severe symptoms and shed live virus as high as 4.13 × 103 plaque-forming units/mL. Infecting genotypes included both variant-of-concern (VOC) and non-VOC strains.
- Subjects
BREAKTHROUGH infections; VIRAL physiology; SARS-CoV-2; ACQUISITION of data methodology; COVID-19 vaccines; RESEARCH methodology; GENETIC variation; INTERVIEWING; SEVERITY of illness index; MESSENGER RNA; MEDICAL records; QUESTIONNAIRES; DESCRIPTIVE statistics; POLYMERASE chain reaction; PHENOTYPES
- Publication
Clinical Infectious Diseases, 2022, Vol 74, Issue 5, p897
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciab543