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- Title
Weight Gain Associated With Integrase Stand Transfer Inhibitor Use in Women.
- Authors
Kerchberger, Anne Marie; Sheth, Anandi N; Angert, Christine D; Mehta, C Christina; Summers, Nathan A; Ofotokun, Ighovwerha; Gustafson, Deborah; Weiser, Sheri D; Sharma, Anjali; Adimora, Adaora A; French, Audrey L; Augenbraun, Michael; Cocohoba, Jennifer; Kassaye, Seble; Bolivar, Hector; Govindarajulu, Usha; Konkle-Parker, Deborah; Golub, Elizabeth T; Lahiri, Cecile D
- Abstract
Background Integrase strand-transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is recommended for human immunodeficiency virus (HIV) management. Although studies have suggested associations between INSTIs and weight gain, women living with HIV (WLHIV) have been underrepresented in research. We evaluated the effect of switching or adding INSTIs among WLHIV. Methods Women enrolled in the Women's Interagency HIV Study (WIHS) from 2006–2017 who switched to or added an INSTI to ART (SWAD group) were compared to women on non-INSTI ART (STAY group). Body weight, body mass index (BMI), percentage body fat (PBF), and waist, hip, arm, and thigh circumferences were measured 6–12 months before and 6–18 months after the INSTI switch/add in SWAD participants, with comparable measurement time points in STAY participants. Linear regression models compared changes over time by SWAD/STAY group, adjusted for age, race, WIHS site, education, income, smoking status, and baseline ART regimen. Results We followed 1118 women (234 SWAD and 884 STAY) for a mean of 2.0 years (+/− 0.1 standard deviation [SD]; mean age 48.8 years, SD +/− 8.8); 61% were Black. On average, compared to the STAY group, the SWAD group experienced mean greater increases of 2.1 kg in body weight, 0.8 kg/m2 in BMI, 1.4% in PBF, and 2.0, 1.9, 0.6, and 1.0 cm in waist, hip, arm, and thigh circumference, respectively (all P values <.05). No differences in magnitudes of these changes were observed by INSTI type. Conclusions In WLHIV, a switch to INSTI was associated with significant increases in body weight, body circumferences, and fat percentages, compared to non-INSTI ART. The metabolic and other health effects of these changes deserve further investigation.
- Subjects
WEIGHT gain risk factors; ADIPOSE tissues; BLACK people; BODY weight; CHI-squared test; COMPARATIVE studies; HIV infections; HIV-positive persons; REGRESSION analysis; RESEARCH funding; SMOKING; WOMEN; SOCIOECONOMIC factors; BODY mass index; HIV integrase inhibitors; DESCRIPTIVE statistics
- Publication
Clinical Infectious Diseases, 2020, Vol 71, Issue 3, p593
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciz853