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- Title
Short Report: Tissue-specific Expression Profiles of the Uncoupling Protein Family in Normal Control Mice and Genetically ob/ob Mice.
- Authors
Chun-Mei Zhang; Min Zhang; Jin-Gai Zhu; Chen-Bo Ji; Chun Zhu; Chun-Zhao Kou; Da-Ni Qin; Mei-Ling Tong; Xi-Rong Guo
- Abstract
Uncoupling proteins (UCPs) located in the inner mitochondrial membrane are involved in the regulation of energy balance. Thus far, 5 UCP isoforms have been identified, but controversies exist in the research focused on the function of the UCPs (except UCP1) in the pathogenesis of obesity. Because of the known cross-reactivity of the antibodies presently available for the detection of UCP proteins, this study systematically analyzed the differential tissue expression profiles of the 5 UCP isoforms in lean control mice and ob/ob mice by using real-time polymerase chain reaction (PCR) analysis. The results show that the tissue-specific expression patterns of individual isoforms in normal and ob/ob mice are considerably different; this will provide new insights into the functions of UCPs in the pathogenesis of genetic obesity.
- Subjects
MITOCHONDRIAL membranes; CELL membranes; BIOENERGETICS; OBESITY; PROTEINS
- Publication
Journal of Bioenergetics & Biomembranes, 2010, Vol 42, Issue 3, p255
- ISSN
0145-479X
- Publication type
Article
- DOI
10.1007/s10863-010-9292-9