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- Title
Association between the PD1.3A/G polymorphism of the PDCD1 gene and systemic lupus erythematosus in European populations: a meta-analysis.
- Authors
Liu, J.-L.; Zhang, F.-Y.; Liang, Y.-H.; Xiao, F.-L.; Zhang, S.-Q.; Cheng, Y.-L.; Yuan, C.-D.; Chen, Q.-P.; Yang, S.; Zhang, X.-J.
- Abstract
Background Linkage studies suggest a locus, SLEB2, involved in susceptibility to systemic lupus erythematosus (SLE) and programmed cell death 1 ( PDCD1) gene locates in this region. The association of PDCD1 polymorphism (PD1.3A/G) with SLE has been widely investigated, but there are no unambiguous conclusions. Objective To assess the combined evidence for the association between PD1.3A/G polymorphism and SLE and to summarize the effect size of the polymorphism associated with susceptibility to SLE. Methods We surveyed studies on the PD1.3A/G polymorphism and SLE using comprehensive PubMed search up to May 2008. The pooled odds ratio (OR) was calculated using a fixed- or a random-effects model. Heterogeneity was identified by sensitivity analysis and publication bias was examined by funnel plot and Egger's test. We also computed the power for a given number of samples. Results A total of 20 datasets from eight studies that met our inclusion criteria were included. The studies comprised of a total of 2909 cases and 3995 controls. Stratified meta-analysis demonstrated a significant association between PD1.3A and SLE among non-Spanish European descents [OR, 1.290; 95% confidence interval (95% CI), 1.098–1.516; z = 3.10, P = 0.002], while PD1.3G is the risk allele in Spanish populations (OR = 1.414, 95% CI = 1.075–1.862; z = 2.48, P = 0.013). Both results have sufficient power to support these findings. No publication bias presented in the studies analysed. Conclusions This meta-analysis demonstrates a significant association between PD1.3A and SLE among non-Spanish European descents, while a negative association was observed in Spanish population. Conflicts of interest None declared
- Subjects
AUTOIMMUNE diseases; SYSTEMIC lupus erythematosus; VASCULAR diseases; SKIN diseases; GENETIC polymorphisms; POPULATION genetics
- Publication
Journal of the European Academy of Dermatology & Venereology, 2009, Vol 23, Issue 4, p425
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/j.1468-3083.2009.03087.x