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- Title
Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator
- Authors
Brellier, Florence; Hostettler, Katrin; Hotz, Hans-Rudolf; Ozcakir, Ceyda; Çöloğlu, Sedat A.; Togbe, Dieudonnée; Ryffel, Bernard; Roth, Michael; Chiquet-Ehrismann, Ruth
- Abstract
Abstract: We explored novel functions of tenascin-C by comparing mouse embryonic fibroblasts (MEFs) proficient or deficient in tenascin-C expression. Transcript profiling analysis identified tissue plasminogen activator (tPA) as the most consistently over-expressed gene in all tenascin-C deficient MEFs. This was confirmed by real-time PCR as well as by protein expression analysis. In agreement with these observations, tenascin-C deficient MEFs had an increased capacity to digest fibrin in situ. Consistently, tenascin-C expression in vivo was found to correlate with fibrin deposition in several diseases associated with tenascin-C overexpression such as fibrosis, asthma and cancer. In conclusion, the present study suggests a new role of tenascin-C as a regulator of the fibrinolytic system.
- Subjects
TENASCIN; FIBRIN; TISSUE plasminogen activator; EXTRACELLULAR matrix; FIBROBLASTS; LABORATORY mice; POLYMERASE chain reaction; GENE expression; FIBROSIS; ASTHMA; CANCER
- Publication
FEBS Letters, 2011, Vol 585, Issue 6, p913
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2011.02.023