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- Title
Experimental Evidence of Effectiveness of VBC-1814/7J, a Poly-Phytocompound, on Inflammatory and Virological Changes in an Influenza-Model.
- Authors
H., Chui D.; K., Kantah M.; H., Sweed; F., He; A., Ayala; U., Solimene; H., Hashizume; K., Kobayashi; Takadanohara, H.; Marotta, F.
- Abstract
Materials & Methods: Fifteen-month old Swiss mice were allocated for 8 days into: A) healthy control; B) infected group and C) as B but treated with 15 mg of the phytocompound VBC-1814/7J divided in two doses mixed with food. Mice were infected intranasally with 30 ml of 75 HA viral units and supplemented at the same time. Results: VBC-1814/7J markedly blunted the signs of virus infection and the febrile response and significantly improved redox balance in BALF and lung tissue (p < 0.05). Moreover, cytokines (TNF-a and IL-6) and chemokine (RANTES) release in BALF was significantly mitigated by the phytocompound with a parallel downregulation of TNF-a and RANTES gene expression in the lungs. Finally, VBC-1814/7J determined a significant decrease of viral load in BALF and lung. Conclusion: The known safety profile and the present data suggest that VBC-1814/7J has potential clinical applications in view also of a preventive regimen.
- Subjects
PHYTOCHEMICALS; ANIMAL experimentation; EXPERIMENTAL design; INFLAMMATION; INFLUENZA; MATHEMATICAL statistics; MICE; HEALTH outcome assessment; T-test (Statistics); VIROLOGY; PARAMETERS (Statistics); TREATMENT effectiveness; DATA analysis software; STATISTICAL models; DESCRIPTIVE statistics; THERAPEUTICS
- Publication
International Medical Journal, 2014, Vol 21, Issue 5, p505
- ISSN
1341-2051
- Publication type
Article