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- Title
Simultaneous cardio-cerebral infarction: a meta-analysis.
- Authors
Ng, T P; Wong, C; Leong, E L E; Tan, B Y; Chan, M Y -Y; Yeo, L L; Yeo, T -C; Wong, R C; Leow, A S; Ho, J S -Y; Sia, C -H
- Abstract
Background/Introduction Cardio-cerebral infarction (CCI), which involves the simultaneous occurrence of acute ischaemic stroke and acute myocardial infarction, has a reported incidence of 0.0009%. Treatment of CCI presents a dilemma to physicians as both conditions are time critical. Despite the need for standardized treatment protocols, published data are sparse. Aim We aimed to summarize the reported cardio-cerebral infarction cases in the literature. Design Meta-analysis. Methods Four databases, Pubmed, Embase, Scopus and Google Scholar were searched until 25 August 2020. A title and abstract sieve, full-text review and extraction of data were conducted independently by three authors. Results A total of 44 cases of CCI were identified from 37 case reports and series; 15 patients (34.1%) were treated using percutaneous coronary intervention (PCI) with stent, 8 patients (18.2%) were treated with a PCI without stent, 10 patients (22.7%) were treated via a cerebral vessel thrombectomy and 8 patients (18.2%) were treated via a thrombectomy of a coronary vessel. For medications, 20 patients (45.5%) were treated with thrombolytics, 10 patients (22.7%) were treated with anticoagulants, 8 patients (18.2%) were treated with antiplatelets and 11 patients (25.0%) were treated with anticoagulants and antiplatelets. Of 44 patients, 10 patients died, and 9 of those were due to cardiac causes. Among the 44 patients, days to death was observed to be a median of 2.0 days (interquartile range (IQR): 1.5, 4.0). The modified Rankin Score was measured in nine patients, with a median score of 2.0 (IQR: 1.0, 2.5) being reported. Discussion/Conclusion The condition of CCI has substantial morbidity and mortality, and further studies are needed to examine the optimal diagnostic and treatment strategies of these patients.
- Subjects
INFARCTION; PERCUTANEOUS coronary intervention; MYOCARDIAL infarction; CORONARY arteries; ISCHEMIC stroke
- Publication
QJM: An International Journal of Medicine, 2022, Vol 115, Issue 6, p374
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcab158