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- Title
Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Treatment of Parkinson's Disease.
- Authors
Subramanian, Leena; Hindle, John V.; Johnston, Stephen; Roberts, Mark V.; Husain, Masud; Goebel, Rainer; Linden, David
- Abstract
Self-regulation of brain activity in humans based on real-time feedback of functional magnetic resonance imaging (fMRI) signal is emerging as a potentially powerful, new technique. Here, we assessed whether patients with Parkinson's disease (PD) are able to alter local brain activity to improve motor function. Five patients learned to increase activity in the supplementary motor complex over two fMRI sessions using motor imagery. They attained as much activation in this target brain region as during a localizer procedure with overt movements. Concomitantly, they showed an improvement in motor speed (finger tapping) and clinical ratings of motor symptom (37o/o improvement of the motor scale of the Unified Parkinson's Disease Rating cal e). Activation during neurofeedback was also observed in other cortical motor areas and the basal ganglia, including the subthalamic nucleus and globus pallidus, which are connected to the supplementary motor area (SMA) and crucial nodes in the pathophysiology of PD. A PD control group of five patients, matched for clinical severity and medication, underwent the same procedure but did not receive feedback about their SMA activity. This group attained no control of SMA activation and showed no motor improvement. These findings demonstrate that self-modulation of corticosubcortical motor circuits can be achieved by PD patients through neurofeedback and may result in clinical benefits that are not attainable by motor imagery alone.
- Subjects
PARKINSON'S disease treatment; MAGNETIC resonance imaging of the brain; BRAIN function localization; CELLULAR signal transduction; MOTOR ability; NEURAL circuitry; PATHOLOGICAL physiology
- Publication
Journal of Neuroscience, 2011, Vol 31, Issue 45, p16309
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.3498-11.2011