We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Monosynaptic and Polysynaptic Feed-Forward Inputs to Mitral Cells from Olfactory Sensory Neurons.
- Authors
Najac, Marion; De Saint Jan, Didier; Reguero, Leire; Grandes, Pedro; Charpak, Serge
- Abstract
Olfactory sensory neurons (OSNs) expressing the same odorant receptor converge in specific glomeruli where they transmit olfactory information to mitral cells. Surprisingly, synaptic mechanisms underlying mitral cell activation are still controversial. Using patch-clamp recordings in mouse olfactory bulb slices, we demonstrate that stimulation of OSNs produces a biphasic postsynaptic excitatory response in mitral cells. The response was initiated by a fast and graded monosynaptic input from OSNs and followed by a slower component of feedforward excitation, involving dendro-dendritic interactions between external tufted, tufted and other mitral cells. The mitral cell response occasionally lacked the fast OSN input when few afferent fibers were stimulated. We also show that OSN stimulation triggers a strong and slow feedforward inhibition that shapes the feedforward excitation but leaves unaffected the monosynaptic component. These results confirm the existence of direct OSN to mitral cells synapses but also emphasize the prominence of intraglomerular feedforward pathways in the mitral cell response.
- Subjects
NERVOUS system; SENSORY neurons; NEURAL transmission; NEURAL circuitry; PLANT products
- Publication
Journal of Neuroscience, 2011, Vol 31, Issue 24, p8722
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.0527-11.2011