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- Title
Proportional Hazards Analysis of Diarrhea due to Enterotoxigenic Escherichia coli and Breast Feeding in a Cohort of Urban Mexican Children.
- Authors
Long, Kurt Z.; Wood, James W.; Gariby, Edgar Vasquez; Weiss, Kenneth M.; Mathewson, John J.; de la Cabada, Francisco J.; DuPont, Herbert L.; Wilson, Richard A.
- Abstract
Ninety-eight women-infant pairs were followed for up to 50 weeks in the northern part of Guadalajara, Mexico, from August 1986 to July 1987 as part of a community-based, prospective study of the relation between infant feeding patterns and enterotoxigenic producing heat-labile toxin (LT-ETEC) diarrheal disease. Strictly formula-fed children had an incidence of diarrhea over three times that of strictly breast fed infants and twice that of breast-fed and supplementally fed children. Strictly formula fed infants colonized by LT-ETEC were symptomatic for diarrhea nearly three times as often as strictly breast-fed infants and twice as often as infants receiving a mixed diet. The fitting of parametric hazard models to durations until LT-ETEC colonization revealed that the hazard for the first colonization was time invariant. The hazard of diarrhea increased by 400–500% during the rainy season or among children 3 months of age or older who received avena, a barley drink. The best-fitting hazard models to durations until symptomatic expression of LT-ETEC infection all increased through time. This hazard was inversely impacted by the overall amount of LT-ETEC-specific, immunoglobulin A antibodies the infant received via the mother's breast milk and by the provision of traditional medicinal teas. 1994;139:193–205.
- Publication
American Journal of Epidemiology, 1994, Vol 139, Issue 2, p193
- ISSN
0002-9262
- Publication type
Article
- DOI
10.1093/oxfordjournals.aje.a116981