We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Phenotype Standardization Project: Improving Pharmacogenetic Studies of Serious Adverse Drug Reactions.
- Authors
Pirmohamed, M.; Aithal, G. P.; Behr, E.; Daly, A.; Roden, D.
- Abstract
The ability to predict the risk for serious drug-induced adverse reactions first requires a large patient database for characterization and validation of genetic markers. The Phenotype Standardization Project (PSP) was initiated to standardize phenotypic definitions, thereby facilitating much-needed recruitment without sacrificing the reliability of patient classification. Three phenotypes have been considered in this initial phase: drug-induced liver injury, drug-induced skin injury, and drug-induced torsade de pointes.
- Subjects
DRUG side effects; GENETIC markers; STANDARDIZATION; PHENOTYPES; LIVER injuries; SKIN injuries
- Publication
Clinical Pharmacology & Therapeutics, 2011, Vol 89, Issue 6, p784
- ISSN
0009-9236
- Publication type
Opinion
- DOI
10.1038/clpt.2011.30