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- Title
Immunohistochemical Detection of Salivary Agglutinin/gp-340 in Human Parotid, Submandibular, and Labial Salivary Glands.
- Authors
Bikker, F. J.; Ligtenberg, A. J. M.; van der Wal, J. E.; van den Keijbus, P. A. M.; Holmskov, U.; Veerman, E. C. I.; Amerongen, A. V. Nieuw
- Abstract
Salivary agglutinin is a Streptococcus mutans binding protein and a member of the scavenger receptor cysteine-rich superfamily. It is identical to lung gp-340 and brain DMBT1, which possibly play a role in innate immunity and tumor suppression, respectively. The goal of this study was to localize salivary agglutinin in human salivary glands. Two monoclonal antibodies, directed against gp-340, were characterized. mAb 213-1 reacted with sialic acid epitopes and crossreacted with MUC7. The reaction with mAb 213-6 disappeared after reduction, suggesting that a protein epitope was recognized. In the parotid gland, immunohistochemical labeling with mAb 213-6 was found in the duct cells. In the submandibular gland and labial gland, both serous acini and demilune cells were labeled. In the labial gland, labeling was found at the luminal side of the duct cells. Salivary agglutinin was distinctly localized in salivary glands, but in distinct glandular secretions, no differences in electrophoretic behavior were observed.
- Subjects
IMMUNOHISTOCHEMISTRY; SALIVA; SALIVARY glands; AGGLUTININS; PAROTID glands; SUBMANDIBULAR gland
- Publication
Journal of Dental Research, 2002, Vol 81, Issue 2, p134
- ISSN
0022-0345
- Publication type
Article
- DOI
10.1177/154405910208100210