We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Association analysis of the lymphocyte-specific protein tyrosine kinase (LCK) gene in type 1 diabetes.
- Authors
Hulme, John S.; Barratt, Bryan J.; Twells, Rebecca C.J.; Cooper, Jason D.; Lowe, Chris E.; Howson, Joanna M.M.; Lam, Alex C.; Smink, Luc J.; Savage, David A.; Undlien, Dag E.; Guja, Cristian; Ionescu-Tîrgoviste, Constantin; Tuomilehto-Wolf, Eva; Tuomilehto, Jaakko; Todd, John A.; Ionescu-Tîirgoviste, Constantin
- Abstract
Prior data associating the expression of lymphocyte-specific protein tyrosine kinase (LCK) with type 1 diabetes, its critical function in lymphocytes, and the linkage of the region to diabetes in the nonobese diabetic (NOD) mouse model make LCK a premier candidate for a susceptibility gene. Resequencing of LCK in 32 individuals detected seven single nucleotide polymorphisms (SNPs) with allele frequencies >3%, including four common SNPs previously reported. These and six other SNPs from dbSNP were genotyped in a two-stage strategy using 2,430 families and were all shown not to be significantly associated with type 1 diabetes. We conclude that a major role for the common LCK polymorphisms in type 1 diabetes is unlikely. However, we cannot rule out the possibility of there being a causal variant outside the exonic, intronic, and untranslated regions studied.
- Subjects
DIABETES; PROTEIN-tyrosine kinases; LYMPHOCYTES; NUCLEOTIDES; PEOPLE with diabetes
- Publication
Diabetes, 2004, Vol 53, Issue 9, p2479
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diabetes.53.9.2479