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- Title
Regulation of insulin-receptor mRNA levels by glucocorticoids.
- Authors
McDonald, Alex R.; Maddux, Betty A.; Okabayashi, Y.; Wong, K. Y.; Hawley, D. M.; Logsdon, Craig D.; Goldfine, Ira D.; McDonald, A R; Maddux, B A; Logsdon, C D; Goldfine, I D
- Abstract
We found with IM-9 human cultured lymphocytes, that the glucocorticoid dexamethasone increased insulin-receptor mRNA levels. This increase correlated in a time- and dose-dependent manner with the increase in the biosynthesis of the insulin-receptor precursor. In addition, in AR42J cultured rat pancreatic acinar cells, dexamethasone increased insulin-receptor mRNA levels. These studies suggest, therefore, that an increase in mRNA levels is an early step in the regulation of the insulin receptor by glucocorticoids in several cell types.
- Publication
Diabetes, 1987, Vol 36, Issue 6, p779
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.36.6.779