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- Title
Prognostic Significance of Lactate Dehydrogenase in Patients Undergoing Surgical Resection for Laryngeal Squamous Cell Carcinoma.
- Authors
Guo, Erliang; Guo, Lunhua; An, Changming; Zhang, Cong; Song, Kaibin; Wang, Guohui; Duan, Chunbin; Zhang, Xiwei; Yang, Xianguang; Yuan, Zhennan; Guo, Junnan; Sun, Ji; Meng, Hongxue; Chang, Rui; Li, Xiaomei; Xiu, Cheng; Mao, Xionghui; Miao, Susheng
- Abstract
The aim is to estimate the prognostic value of lactate dehydrogenase (LDH) in patients undergoing surgical resection for laryngeal squamous cell carcinoma (LSCC). A total of 640 resected LSCC patients were included. Preoperative lactate dehydrogenase (LDH) was assessed. Kaplan-Meier survival analysis and Cox regression analysis were conducted for overall survival (OS) and recurrence-free survival (RFS). Kaplan-Meier analysis, univariate analysis and multivariate analysis demonstrated significant prognostic value for preoperative LDH. Although LDH was predictor of OS, it failed to be a predictor of RFS. The univariate HR and 95% CI of LDH were 0.484 and 0.357-0.658 (P < 0.0001). The multivariate analysis showed that LDH (HR = 0.518, 95% CI: 0.380-0.705, p < 0.0001) was related to OS. Elevated preoperative LDH >132 IU/L was significantly associated with better survival. Preoperative LDH might be an independent prognostic marker of OS in LSCC patients undergoing surgical resection.
- Publication
Cancer Control: Journal of the Moffitt Cancer Center, 2020, Vol 27, Issue 1, p1
- ISSN
1073-2748
- Publication type
journal article
- DOI
10.1177/1073274820978795