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- Title
Effects of tumor metabolic microenvironment on regulatory T cells.
- Authors
Wang, Yi-an; Li, Xiao-Ling; Mo, Yong-Zhen; Fan, Chun-Mei; Tang, Le; Xiong, Fang; Guo, Can; Xiang, Bo; Zhou, Ming; Ma, Jian; Huang, Xi; Wu, Xu; Li, Yong; Li, Gui-Yuan; Zeng, Zhao-yang; Xiong, Wei
- Abstract
Recent studies have shown that on one hand, tumors need to obtain a sufficient energy supply, and on the other hand they must evade the body's immune surveillance. Because of their metabolic reprogramming characteristics, tumors can modify the physicochemical properties of the microenvironment, which in turn affects the biological characteristics of the cells infiltrating them. Regulatory T cells (Tregs) are a subset of T cells that regulate immune responses in the body. They exist in large quantities in the tumor microenvironment and exert immunosuppressive effects. The main effect of tumor microenvironment on Tregs is to promote their differentiation, proliferation, secretion of immunosuppressive factors, and chemotactic recruitment to play a role in immunosuppression in tumor tissues. This review focuses on cell metabolism reprogramming and the most significant features of the tumor microenvironment relative to the functional effects on Tregs, highlighting our understanding of the mechanisms of tumor immune evasion and providing new directions for tumor immunotherapy.
- Subjects
TUMOR microenvironment; T cells; IMMUNOSUPPRESSIVE agents; CELLULAR signal transduction; IMMUNOTHERAPY; IMMUNE response
- Publication
Molecular Cancer, 2018, Vol 17, Issue 1, pN.PAG
- ISSN
1476-4598
- Publication type
Article
- DOI
10.1186/s12943-018-0913-y