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- Title
Evaluation and identification of factors related to and gene mutations in colorectal cancer: A meta-analysis.
- Authors
Li Lin; Guang-yong Chen; Chun-wei Xu; Hai-yan Wang; Yong-fang Wu; Mei-yu Fang; Lin, Li; Chen, Guang-Yong; Xu, Chun-Wei; Wang, Hai-Yan; Wu, Yong-Fang; Fang, Mei-Yu
- Abstract
<bold>Objective: </bold>The aim of this meta-analysis is to evaluate the distribution pattern of KRAS and BRAF mutations in colorectal cancer.<bold>Materials and Methods: </bold>The database was searched without language restrictions. Meta-analyses were conducted using the STATA software. We calculated the odds ratio (OR) and its 95% confidence interval (95% CI) to estimate the distribution of and correlation between KRAS and BRAF mutations, CpG island methylator phenotype (CIMP), and microsatellite instability (MSI) in left- and right-sided colorectal cancer.<bold>Results: </bold>The studies were divided into five groups: (1) distribution of KRAS/BRAF mutations in distal and proximal colorectal cancer, the summary OR value was 1.24 versus 4.03, (2) distribution of KRAS/BRAF mutations in CIMP-low/Neg and CIMP-high (CIMP-H) tumors, the summary OR value was 0.77 versus 10.49, (3) distribution of KRAS/BRAF mutations in MSI-low (MSI-L)/microsatellite stable (MSS) and MSI-high (MSI-H) tumors, the summary OR value was 0.51 versus 9.60, (4) proportion of CIMP-H/MSI-H tumors among distal and proximal colorectal tumors, the summary OR value was 3.66 versus 6.54, and (5) proportion of CIMP-H tumors among MSI-L/MSS and MSI-H tumors, the summary OR value was 5.87.<bold>Conclusion: </bold>The meta-analysis reveals that KRAS has a slightly higher mutation rate in MSI-L/MSS tumors. Moreover, BRAF mutations have higher detection rates in right-sided colorectal cancer, which suggests that BRAF mutations are likely in CIMP-H tumors. Therefore, based on these findings, the molecular diagnostic tests to be conducted in colorectal cancer patients can be determined according to the location/clinical features of the tumor.
- Subjects
GENETICS of colon cancer; COLON cancer diagnosis; BRAF genes; COLON cancer treatment; META-analysis; GENETIC mutation
- Publication
Journal of Cancer Research & Therapeutics, 2016, Vol 12, Issue 7, pC191
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/0973-1482.200601