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- Title
Chemotherapy effectively suppresses interleukin-20, receptor activator of nuclear factor kappa-B ligand, and osteoprotegerin levels in patients with lung adenocarcinoma and bone metastasis.
- Authors
Mingyang Yu; Yun Su; Daping Cui; Qiang Sun; Bowu Luan; Dewei Zhao; Yu, Mingyang; Su, Yun; Cui, Daping; Sun, Qiang; Luan, Bowu; Zhao, Dewei
- Abstract
<bold>Background: </bold>Bone metastasis (BM) is common in patients with lung cancer. Osteolysis is caused by increased osteoclast activity. Interleukin-20 (IL-20) and receptor activator of nuclear factor kappa-B ligand (RANKL) are crucial for osteoclast formation. Osteoprotegerin (OPG) inhibits a receptor activator of RANKL/RANK signaling. The aims of this study were to analyze the serum levels of IL-20, OPG, and RANKL in patients with and without BM and to observe the effect of chemotherapy on these cytokines.<bold>Patients and Methods: </bold>A total 54 cases of pathologically confirmed lung adenocarcinoma (ADC) and 18 healthy individuals (Control) were enrolled in this study. Eligible patients were divided into three groups (18 patients per group): ADC without BM (ADC), ADC with BM (ADC + BM), and ADC with BM treated with chemotherapy (ADC + BM + Chemo). Serum IL-20, RANKL, and OPG levels were analyzed by enzyme-linked immunosorbent assay.<bold>Results: </bold>Serum IL-20, RANKL, and OPG levels in ADC + BM patients were significantly elevated compared with that in the Control or ADC groups (both P < 0.001). The serum cytokine levels were significantly lower following chemotherapy compared with that in patients who did not receive chemotherapy (P < 0.001).<bold>Conclusions: </bold>Serum IL-20, RANKL, and OPG levels increase in patients with lung cancer and BMs. Chemotherapy suppresses the elevation of these cytokines.
- Subjects
CANCER chemotherapy; INTERLEUKIN receptors; NF-kappa B; OSTEOPROTEGERIN; BONE metastasis; ANTINEOPLASTIC agents; ADENOCARCINOMA; BONE tumors; CELL receptors; INTERLEUKINS; LUNG tumors; MEMBRANE proteins; CASE-control method; BLOOD
- Publication
Journal of Cancer Research & Therapeutics, 2016, Vol 12, Issue 2, p963
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/0973-1482.179085