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- Title
Cross-sectionally assessed carotid intima-media thickness relates to long-term risk of stroke, coronary heart disease and death as estimated by available risk functions.
- Authors
Bots, M. L.; Hoes, A. W.; Hofman, A.; Witteman, J. C. M.; Grobbee, D. E.; Witteman, J C
- Abstract
<bold>Objective: </bold>To relate cross-sectionally assessed indicators of carotid atherosclerosis measured in participants of the Rotterdam Study to absolute 10-12 year risks of stroke, coronary heart disease and death estimated by risk functions available from other studies.<bold>Setting: </bold>General population living in the suburb of Ommoord in Rotterdam, The Netherlands.<bold>Subjects: </bold>A sample of men and women (n = 1683), aged 55 years or over, drawn from participants from the Rotterdam Study (n = 7983).<bold>Main Outcomes Measures: </bold>Three risk scores were used to estimate for each individual the absolute risk of stroke, coronary heart disease and death within 10-12 years as a function of their cardiovascular risk factor profile. Cross-sectionally measured indicators of carotid atherosclerosis (presence of atherosclerotic lesions and common carotid intima-media thickness) were subsequently related to these risk scores.<bold>Results: </bold>The 10-year absolute risk of stroke increased linearly from 4.8% (95% CI = 3.8, 5.8) for subjects in the lowest quintile to 16.1% (12.3, 21.9) for subjects in the highest quintile of common carotid intima-media thickness distribution. Similarly, the 10-year absolute risk for coronary heart disease rose from 13.1% (95% CI = 12.0, 14.2) to 23.4% (95% CI = 21.4, 25.4), whereas the risk of death within 11.5 years rose from 15.0% (95% CI = 12.8, 17.4) in the lowest quintile to 46.0% (42.8, 49.3) in the upper quintile. The absolute risks of stroke, coronary heart disease or death rose from 8.8, 15.8 and 26.9% to 14.3, 19.8 and 40.9%, respectively, when plaques in the common carotid artery were present. Similar findings were observed for plaques in the carotid bifurcation.<bold>Conclusion: </bold>Common carotid intima-media thickness and carotid plaques are markers for increased risk of stroke, coronary heart disease and death within 10-12 years.
- Subjects
ATHEROSCLEROSIS risk factors; CAROTID artery diseases; ARTERIAL occlusions; CEREBROVASCULAR disease risk factors; CORONARY heart disease risk factors; DISEASE risk factors
- Publication
Journal of Internal Medicine, 1999, Vol 245, Issue 3, p269
- ISSN
0954-6820
- Publication type
journal article
- DOI
10.1046/j.1365-2796.1999.0442f.x