We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Association between +1059G/C CRP Polymorphism and Acute Myocardial Infarction in a Cohort of Patients from Sicily.
- Authors
BALISTRERI, CARMELA RITA; VASTO, SONYA; LISTÌ, FLORINDA; GRIMALDI, MARIA PAOLA; LIO, DOMENICO; COLONNA‐ROMANO, GIUSEPPINA; CARUSO, MARCO; CAIMI, GREGORIO; HOFFMANN, ENRICO; CARUSO, CALOGERO; CANDORE, GIUSEPPINA
- Abstract
Inflammation plays a role in all the phases of atherosclerosis, and increased production of the acute-phase reactant, C-reactive protein (CRP), predicts future cardiovascular events. Furthermore, CRP has been claimed to play a role in the pathogenesis of atherosclerosis; therefore, CRP polymorphisms might be associated with acute myocardial infarction (AMI). We have analyzed male patients affected by AMI and healthy age-related male controls from Sicily for +1059G/C CRP single-nucleotide polymorphism (SNP). There was a significantly higher frequency of +1059C SNP ( P= 0.0008; OR 3.86) in patients compared to controls. CRP serum levels were significantly higher in C+ healthy subjects rather than in C− subjects ( P= 0.0075). The results of the present pilot case–control study performed in a homogeneous caucasoid population suggest that +1059C CRP gene SNP is associated with AMI. In any case, the results of the present study should add to the growing body of evidence on the role of pro-inflammatory genotypes in unsuccessful aging, determining susceptibility to immune-inflammatory diseases such as coronary heart disease.
- Subjects
MYOCARDIAL infarction; CORONARY disease; IMMUNOGENETICS; INFLAMMATION; CARDIAC patients
- Publication
Annals of the New York Academy of Sciences, 2006, Vol 1067, Issue 1, p276
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1354.036