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- Title
The efficacy of a subhypnotic dose of propofol in preventing laryngospasm following tonsillectomy and adenoidectomy in children.
- Authors
Batra, Yatindra Kumar; Ivanova, Maya; Ali, Syed Shujat; Shamsah, Mohammed; Al Qattan, Abdul Raheem; Belani, Kumar G.
- Abstract
Background: Laryngospasm is a well-known problem typically occurring immediately following tracheal extubation. Propofol is known to inhibit airway reflexes. In this study, we sought to assess whether the empiric use of a subhypnotic dose of propofol prior to emergence will decrease the occurrence of laryngospasm following extubation in children. Methods: After approval from the Institutional Ethics Committee and informed parental consent, we enrolled 120 children ASA physical status I and II, aged 3–14 years who were scheduled to undergo elective tonsillectomy with or without adenoidectomy under standard general anesthesia. Before extubation, the patients were randomized and received in a blinded fashion either propofol 0.5 mg·kg−1 or saline (control) intravenously. Tracheal extubation was performed 60 s after administration of study drug, when the child was breathing regularly and reacting to the tracheal tube. Results: Laryngospasm was seen in 20% ( n = 12) of the 60 children in the control group and in only 6.6% ( n = 4) of 60 children in the propofol group ( P < 0.05). Conclusions: During emergence from inhalational anesthesia, propofol in a subhypnotic dose (0.5 mg·kg−1) decreases the likelihood of laryngospasm upon tracheal extubation in children undergoing tonsillectomy with or without adenoidectomy.
- Subjects
DRUG efficacy; TONSIL diseases; TONSILLECTOMY; ADENOIDECTOMY; ADENOID surgery; PEDIATRIC surgery; PEDIATRIC anesthesia
- Publication
Pediatric Anesthesia, 2005, Vol 15, Issue 12, p1094
- ISSN
1155-5645
- Publication type
Article
- DOI
10.1111/j.1460-9592.2005.01633.x