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- Title
Comparison of 3- Year Clinical Outcomes Between Resolute™ Zotarolimus- and Sirolimus- Eluting Stents for Long Coronary Artery Stenosis.
- Authors
IM, EUI; KIM, BYEONG‐KEUK; KO, YOUNG‐GUK; HER, AE‐YOUNG; CHOI, HYUN HEE; SHIN, DONG‐HO; KIM, JUNG‐SUN; CHOI, DONGHOON; JANG, YANGSOO; HONG, MYEONG‐KI
- Abstract
Objectives Long-term clinical outcomes were evaluated in long coronary artery stenosis treated with different types of drug-eluting stents. Background Long-term follow-up data to compare clinical outcomes between Resolute™ zotarolimus-eluting stent (R-ZES) versus sirolimus-eluting stent (SES) implantation for long coronary artery stenosis is insufficient. Methods A total of 254 patients (307 lesions) treated with R-ZES and 265 patients (303 lesions) treated with SES for long coronary lesions (total stent length ≥30 mm) were enrolled, and long-term (3 years) clinical outcomes were compared between the 2 groups. Efficacy (target lesion revascularization [TLR]) and safety (the composite occurrence of cardiovascular death, target lesion-related myocardial infarction, or target lesion-related definite stent thrombosis) were assessed. Results The 2 groups had similar baseline characteristics except for the duration of dual antiplatelet therapy (23.4 ± 11.2 months in R-ZES-treated patients vs. 27.4 ± 13.9 months in SES-treated patients, P < 0.001). Total stent length was similar in R-ZES-treated patients (45.0 ± 19.0 mm) and SES-treated patients (45.4 ± 18.6 mm) (P = 0.464). The cumulative TLR rate was 4.6% in R-ZES-treated patients versus 4.6% in SES-treated patients (P = 0.911). For safety parameters, R-ZES-treated patients showed a significantly lower rate of the composite occurrence of cardiovascular death, target lesion-related myocardial infarction, or target lesion-related definite stent thrombosis than SES-treated patients (0.4% vs. 2.4%, P = 0.042). Particularly, the occurrence of target lesion-related definite stent thrombosis was significantly lower in R-ZES-treated patients than in SES-treated patients (0.0% vs. 2.0%, P = 0.028). Conclusions R-ZES stents showed superior long-term safety than SES for treating long coronary lesions, while maintaining a similar clinical efficacy.
- Subjects
CORONARY artery stenosis; HEALTH outcome assessment; RAPAMYCIN; DRUG-eluting stents; TARGETED drug delivery; CLINICAL trials; THERAPEUTICS
- Publication
Journal of Interventional Cardiology, 2013, Vol 26, Issue 4, p378
- ISSN
0896-4327
- Publication type
Article
- DOI
10.1111/joic.12047