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- Title
Engineering Cytochrome-Modified Silica Nanoparticles To Induce Programmed Cell Death.
- Authors
Huang, Wen‐Yen; Davies, Gemma‐Louise; Davis, Jason J.
- Abstract
A low native membrane permeability and ineffective access to the cellular cytosol, together with aggressive proteolytic degradation, often severely hampers the practical application of any therapeutic protein or antibody. Through engineering the charging profile of mesoporous silica nanoparticles, cellular uptake and subsequent subcellular distribution can be controlled. We show herein that programmed cell death can subsequently be induced across a population of cancer cells with remarkable efficacy on conjugating a specific caspase-cascade-activating cytochrome to such cytosol-accessing particles.
- Subjects
CYTOCHROMES; IMMUNOGLOBULINS; CANCER cells; CYTOSOL; NANOPARTICLES; CELL death; PROTEOLYSIS
- Publication
Chemistry - A European Journal, 2013, Vol 19, Issue 52, p17891
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201303239