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- Title
A Strategy Enabling Enantioselective Direct Conjugate Addition of Inert Aryl Methane Nucleophiles to Enals with a Chiral Amine Catalyst under Mild Conditions.
- Authors
Li, Tengfei; Zhu, Jin; Wu, Deyan; Li, Xiangmin; Wang, Sinan; Li, Hao; Li, Jian; Wang, Wei
- Abstract
Nitro‐charged activation: An organocatalytic enantioselective conjugate addition of aryl methyl nucleophiles to enals has been developed to produce ubiquitous chiral benzylic building blocks (see scheme; TES=triethylsilyl). Taking advantage of the strongly electron‐withdrawing nature of nitro groups, which can be conveniently transformed into other functionalities, this functionality was incorporated into aromatic systems as a temporary activating group.
- Subjects
AROMATIC compounds; ASYMMETRIC synthesis; CHEMICAL reactions; CHEMICAL decomposition; POLLUTANTS; METHYL groups
- Publication
Chemistry - A European Journal, 2013, Vol 19, Issue 28, p9147
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201300304