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- Title
Snapshot CEST++: Advancing rapid whole‐brain APTw‐CEST MRI at 3 T.
- Authors
Sedykh, Maria; Liebig, Patrick; Herz, Kai; Fabian, Moritz S.; Mennecke, Angelika; Weinmüller, Simon; Schmidt, Manuel; Dörfler, Arnd; Zaiss, Moritz
- Abstract
APTw CEST MRI suffers from long preparation times and consequently long acquisition times (~5 min). Recently, a consensus on the preparation module for clinical APTw CEST at 3 T was found in the community, and we present a fast whole‐brain APTw CEST MRI sequence following this consensus preparation of pulsed RF irradiation of 2 s duration at 90% RF duty‐cycle and a B1,rms of 2 μT. After optimization of the snapshot CEST approach for APTw imaging regarding flip angle, voxel size and frequency offset sampling, we extend it by undersampled GRE acquisition and compressed sensing reconstruction. This allows 2 mm isotropic whole‐brain APTw imaging for clinical research at 3 T below 2 min. With this sequence, a fast snapshot APTw imaging method is now available for larger clinical studies of brain tumors.
- Subjects
MAGNETIC resonance imaging; BRAIN tumors; DIAGNOSTIC imaging; MEDICAL research
- Publication
NMR in Biomedicine, 2023, Vol 36, Issue 10, p1
- ISSN
0952-3480
- Publication type
Article
- DOI
10.1002/nbm.4955