We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Association of midregional proadrenomedullin with coronary artery stenoses, soft atherosclerotic plaques and coronary artery calcium.
- Authors
Roos, Marcel; Schuster, Tibor; Ndrepepa, Gjin; Baumann, Marcus; Lutz, Jens; Braun, Siegmund; Martinof, Stefan; Schömig, Albert; Heemann, Uwe; Kastrati, Adnan; Hausleiter, Jörg
- Abstract
Midregional proadrenomedullin (MR-proADM) is elevated in patients with heart failure and myocardial infarction. The aim of this study was to evaluate the association of MR-proADM with the grade of coronary artery stenosis, presence of coronary artery soft plaques and coronary artery calcification score (CACS), determined by 64-multislice computed tomography (MSCT) in patients without known prior cardiovascular disease. This retrospective study included 107 patients undergoing MSCT for confirmation (or exclusion) of coronary artery disease. MR-proADM levels were measured in all patients. The assessment of coronary artery stenoses, CACS and soft coronary plaques was made by MSCT using known criteria. The MR-proADM [median (25th-75th percentiles)] level was 0.33 (0.21-0.43) nmol/l. The MR-proADM level was 0.28 (0.22-0.40) nmol/l in patients with coronary stenoses ≥50% ( n = 23) versus 0.33 (0.27-0.40) nmol/l in patients with coronary stenoses <50% ( n = 83, P = 0.59), 0.33 (0.26-0.40) nmol/l in patients with soft plaques ( n = 56) versus 0.33 (0.25-0.41) nmol/l in patients without soft plaques ( n = 50, P = 0.73) and 0.33 (0.25-0.39) nmol/l in patients with CACS <200 ( n = 81) versus 0.32 (0.26-0.44) nmol/l in patients with CACS ≥200 ( n = 26, P = 0.77). In multivariate analysis, the MR-proADM level was a significant correlate of coronary artery stenoses [odds ratio (OR) = 0.93; 95% confidence interval (CI) 0.86-0.99; P = 0.026] and soft plaques (OR = 0.94; 95% CI 0.90-0.99; P = 0.015) but not of CACS (OR = 0.98; 95% CI 0.93-1.03; P = 0.36). A decreased MR-proADM level is an independent correlate of the presence of coronary artery disease and of soft atherosclerotic plaques. Patients with decreased MR-proADM levels may need invasive examinations to diagnose more severe forms of coronary artery disease.
- Subjects
CORONARY artery stenosis; CALCIUM in the body; ADRENOMEDULLIN; ATHEROSCLEROTIC plaque; MYOCARDIAL infarction; TOMOGRAPHY; MULTIVARIATE analysis; PATIENTS
- Publication
Heart & Vessels, 2012, Vol 27, Issue 4, p352
- ISSN
0910-8327
- Publication type
Article
- DOI
10.1007/s00380-011-0166-9