We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Aqueductal Cerebrospinal Fluid Pulsatility in Healthy Individuals Is Affected by Impaired Cerebral Venous Outflow.
- Authors
Beggs, Clive B.; Magnano, Christopher; Shepherd, Simon J.; Marr, Karen; Valnarov, Vesela; Hojnacki, David; Bergsland, Niels; Belov, Pavel; Grisafi, Steven; Dwyer, Michael G.; Carl, Ellen; Weinstock‐Guttman, Bianca; Zivadinov, Robert
- Abstract
Purpose: To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius (AoS) in chronic cerebrospinal venous insufficiency (CCSVI)-positive and - negative healthy individuals using cine phase contrast imaging. Materials and Methods: Fifty-one healthy individuals (32 CCSVI-negative and 19 age-matched CCSVI-positive subjects) were examined using Doppler sonography (DS). Diagnosis of CCSVI was established if subjects fulfilled ⩾2 venous hemodynamic criteria on DS. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and routine 3T MRI outcomes. Results: CCSVI was associated with increased CSF pulsatility in the AoS. Net positive CSF flow was 32% greater in the CCSVI-positive group compared with the CCSVInegative group (P = 0.008). This was accompanied by a 28% increase in the mean aqueductal characteristic signal (ie, the AoS cross-sectional area over the cardiac cycle) in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.021). Conclusion: CSF dynamics are altered in CCSVI-positive healthy individuals, as demonstrated by increased pulsatility. This is accompanied by enlargement of the AoS, suggesting that structural changes may be occurring in the brain parenchyma of CCSVI-positive healthy individuals.
- Publication
Journal of Magnetic Resonance Imaging, 2014, Vol 40, Issue 5, p1115
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.24468