We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Quantitative effects of inclusion of fat on muscle diffusion tensor MRI measurements.
- Authors
Williams, Sarah E.; Heemskerk, Anneriet M.; Welch, E. Brian; Li, Ke; Damon, Bruce M.; Park, Jane H.
- Abstract
Purpose To determine the minimum water percentage in a muscle region of interest that would allow diffusion tensor (DT−) MRI data to reflect the diffusion properties of pure muscle accurately. Materials and Methods Proton density-weighted images with and without fat saturation were obtained at the mid-thigh in four subjects. Co-registered DT-MR images were used to calculate the diffusion tensor's eigenvalues and fractional anisotropy. Results The eigenvalues transitioned monotonically as a function of water signal percentage from values near to those expected for pure fat to those for pure muscle. Also, the fractional anisotropy transitioned monotonically from 0.50 (fat) to 0.20 (muscle). For water signal percentages >55%, none of the diffusion indices differed significantly from those for regions of >90% muscle. Conclusion Accounting for the T 1 and T 2 values of muscle and fat and the pulse sequence properties, it is concluded that, as a conservative estimate, regions must contain at least 76% muscle tissue to reflect the diffusion properties of pure muscle accurately. J. Magn. Reson. Imaging 2013;38:1292-1297. © 2013 Wiley Periodicals, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2013, Vol 38, Issue 5, p1292
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.24045