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- Title
The role of afferent renal denervation in renovascular hypertension—another brick in the wall.
- Authors
Kiuchi, Márcio Galindo; Chen, Shaojie; Carnagarin, Revathy; Schlaich, Markus P.
- Abstract
In their elegant study, Lopes and colleagues [[6]] described that chemical afferent renal denervation (ARD) decreased blood pressure (BP), renal sympathetic nerve activity (rSNA) and reactive oxygen species (ROS) in both kidneys and normalized renal function, proteinuria and activation of intrarenal renin-angiotensin system (RAS) in renovascular hypertensive animals. These data demonstrate that afferent renal nerves are crucial for the maintenance of BP and renal sympathetic hyperactivation, as well as renal function, in the renovascular hypertension model [[6]]. Afferent renal nerve ablation leads to the mitigation of sympathetic signals arising from the kidneys to the brain, which per se lowers central sympathetic outflow ultimately reducing the efferent sympathetic nerve signalling to key organs.
- Subjects
RENOVASCULAR hypertension; AFFERENT pathways; DENERVATION; BRICK walls; BLOOD pressure; VASOCONSTRICTION; CARDIOVASCULAR diseases risk factors
- Publication
Pflügers Archiv: European Journal of Physiology, 2020, Vol 472, Issue 3, p323
- ISSN
0031-6768
- Publication type
Editorial
- DOI
10.1007/s00424-020-02354-9