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- Title
Naphthalene Diimides Carrying Two β-Cyclodextrins Prefer Telomere RNA G-Quadruplex Recognition.
- Authors
Zou, Tingting; Sato, Yuka; Kaneyoshi, Shuma; Mano, Kota; Yasukawa, Rui; Nakano, Yoshifumi; Fujii, Satoshi; Sato, Shinobu; Takenaka, Shigeori
- Abstract
Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. The binding simulation indicated that β-cyclodextrins might be available for loop nucleobase inclusion under its complex.
- Subjects
TELOMERES; NAPHTHALENE; RNA; CYCLODEXTRINS; CYCLODEXTRIN derivatives; INCLUSION compounds; IMIDES
- Publication
Molecules, 2022, Vol 27, Issue 13, p4053
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27134053