We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Ethanolic Extract from Pteris wallichiana Alleviates DSS-Induced Intestinal Inflammation and Intestinal Barrier Dysfunction by Inhibiting the TLR4/NF-κB Pathway and Regulating Tight Junction Proteins.
- Authors
Tao, Junhong; Huang, Zhihua; Wang, Yudan; Liu, Yaping; Zhao, Tianrui; Wang, Yifen; Tian, Lei; Cheng, Guiguang
- Abstract
The aim of the research was to determine the protective effect and mechanism of Pteris wallichiana J. Agardh extract (PWE) on DSS-induced ulcerative colitis (UC) in mice. In this research, PWE is rich in flavonoids and diterpenoids by UPLC-MS/MS analysis. In LPS-induced RAW264.7 cells, PWE reduced the productions of inflammatory factors (i.e., NO, TNF-α, IL-6, and IL-1β). In DSS-induced UC in mice, PWE improved disease activity index (DAI) score, attenuated oxidative stress by decreasing MPO and MDA activities and activating GSH and SOD levels, and inhibited TNF-α, IL-6, and IL-1β expressions in the colonic tissues. PWE also improved the intestinal barrier by upregulating the expressions of tight junction proteins, including occludin and ZO-1. Moreover, PWE extract alleviated intestinal inflammation by suppressing the TLR4/MyD88/NF-κB signaling pathway. Conclusion: PWE can alleviate DSS-induced UC in mice by increasing the expressions of intestinal tight junction proteins and inhibiting the TLR4/NF-κB inflammatory pathway.
- Subjects
OCCLUDINS; PTERIS; INTESTINES; ULCERATIVE colitis; PROTEINS; INFLAMMATION; TIGHT junctions
- Publication
Molecules, 2022, Vol 27, Issue 10, p3093
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27103093