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- Title
Role of the p-Coumaroyl Moiety in the Antioxidant and Cytoprotective Effects of Flavonoid Glycosides: Comparison of Astragalin and Tiliroside.
- Authors
Xican Li; Yage Tian; Tingting Wang; Qiaoqi Lin; Xiaoyi Feng; Qian Jiang; Yamei Liu; Dongfeng Chen
- Abstract
The aim of this study was to explore the role of p-coumaroyl in the antioxidant and cytoprotective effects of flavonoid glycosides. The antioxidant effects of astragalin and tiliroside were compared using ferric ion reducing antioxidant power, DPPHα scavenging, ABTSα+ scavenging, αO2- scavenging, and Fe2+-chelating assays. The results of these assays revealed that astragalin and tiliroside both exhibited dose-dependent activities; however, tiliroside exhibited lower IC50 values than astragalin. In the Fe2+-chelating assay, tiliroside gave a larger shoulder-peak at 510 nm than astragalin, and was also found to be darker in color. Both of these compounds were subsequently evaluated in a Fenton-induced mesenchymal stem cell (MSC) damaged assay, where tiliroside performed more effectively as a cytoprotective agent than astragalin. Tiliroside bearing a 6"-O-p-coumaroyl moiety exhibits higher antioxidant and cytoprotective effects than astragalin. The 6"-O-p-coumaroyl moiety of tiliroside not only enhances the possibility of electron-transfer and hydrogen-atom-transfer-based multi-pathways, but also enhances the likelihood of Fe-chelating. The p-coumaroylation of the 6"-OH position could therefore be regarded as a potential approach for improving the antioxidant and cytoprotective effects of flavonoid glycosides in MSC implantation therapy.
- Subjects
FLAVONOID glycosides; OXIDANT status; CYTOPROTECTION; MESENCHYMAL stem cells; IRON ions
- Publication
Molecules, 2017, Vol 22, Issue 7, p1165
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22071165