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- Title
One Lignanoid Compound and Four Triterpenoid Compounds with Anti-Inflammatory Activity from the Leaves of Elaeagnus oldhamii Maxim.
- Authors
Chi-Ren Liao; Yu-Ling Ho; Guan-Jhong Huang; Chang Syun Yang; Che-Yi Chao; Yuan-Shiun Chang; Yueh-Hsiung Kuo
- Abstract
One lignanoid compound, isoamericanol B (1), along with four triterpenoid compounds-cis-3-O-p-hydroxycinnamoyloleanolic acid (2), trans-3-O-p-hydroxy cinnamoyloleanolic acid (3), cis-3-O-p-hydroxycinnamoylursolic acid (4), trans-3-O-phydroxycinnamoylursolic acid (5) have been isolated for the first time from the leaves of Elaeagnus oldhamii Maxim. Compounds 1-4 significantly inhibited the expression of NO (nitric oxide) produced in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The IC50 value for inhibition of nitrite production of compound 1 was about 10.3 ± 0.4 μg/mL. In the cell viability test, however, among compounds 1-4 compound 1 did not significantly change cell viability. Therefore, in this study compound 1 possessed anti-inflammatory effects. The result suggests compound 1 as a potential lead compound for the treatment of inflammatory diseases.
- Subjects
TRADITIONAL medicine; HERBAL medicine; ELAEAGNUS; TRITERPENOIDS; ANTI-inflammatory agents; NITRITES
- Publication
Molecules, 2013, Vol 18, Issue 11, p13218
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules181113218