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- Title
Industrial-Scale Preparation of Akebia Saponin D by a Two-Step Macroporous Resin Column Separation.
- Authors
Yue Wu; De Ji; Yunfei Liu; Chunfeng Zhang; Zhonglin Yang
- Abstract
A simple and efficient procedure for the industrial preparation of akebia saponin D, one of the bioactive compounds commonly found in the well-known Chinese Medicinal herb Dipsaci Radix, was developed. First, HPD-722 was selected from among 10 kinds of macroporous absorption resins. Following this step, the purity of akebia saponin D was increased about 10 times from 6.27% to 59.41%. In order to achieve a higher purity, ADS-7 was chosen from among five kinds of macroporous absorption resins, and the purity of akebia saponin D was increased from 59.41% to 95.05%. The result indicated HPD-722 and ADS-7 were the most suitable resins to purify akebia saponin D from Dipsaci Radix. Under these conditions, large-scale preparation of akebia saponin D was carried out successfully. The preparation method is simple, efficient, and has been demonstrated to be effective for large scale preparations of akebia saponin D from Dipsaci Radix.
- Subjects
SAPONINS; HERBAL medicine; BIOACTIVE compounds; DIPSACACEAE; TREATMENT of bone diseases; CHEMICAL structure
- Publication
Molecules, 2012, Vol 17, Issue 7, p7798
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules17077798