We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Alkaloids from Hippeastrum papilio.
- Authors
de Andrade, Jean Paulo; Berkov, Strahil; Viladomat, Francesc; Codina, Carles; Zuanazzi, José Angelo S.; Bastida, Jaume
- Abstract
Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer's disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkaloids for the treatment of AD. In this paper we report the isolation of the new alkaloid 11β-hydroxygalanthamine, an epimer of the previously isolated alkaloid habranthine, which was identified using NMR techniques. It has been shown that 11β-hydroxygalanthamine has an important in vitro acetylcholinesterase inhibitory activity. Additionally, Hippeastrum papilio yielded substantial quantities of galanthamine.
- Subjects
ACETYLCHOLINESTERASE; ALZHEIMER'S disease treatment; THERAPEUTIC use of alkaloids; AMARYLLIDACEAE; CHEMICAL inhibitors
- Publication
Molecules, 2011, Vol 16, Issue 8, p7097
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules16087097