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- Title
Substituted N-Phenylpyrazine-2-carboxamides: Synthesis and Antimycobacterial Evaluation.
- Authors
Doležal, Martin; Zitko, Jan; Kešetovicová, Diana; Kuneš, Jirí; Svobodová, Michaela
- Abstract
The condensation of chlorides of substituted pyrazinecarboxylic acids with ringsubstituted anilines yielded twelve substituted pyrazinecarboxylic acid amides. The synthetic approach, analytical, and lipophilicity data of the newly synthesized compounds are presented. Two antituberculosis assays were used. Firstly, the antimycobacterial activity against four different Mycobacterium strains in a series of pyrazine derivatives was investigated. Secondly, the antimycobacterial evaluation was performed at the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) program. Interesting in vitro antimycobacterial activity was found, N-(3-iodo-4-methylphenyl) pyrazine-2-carboxamide (9) was most active derivative compound against M. tuberculosis (MIC < 2.0 μmol/L), while another iodo derivative 5-tert-butyl-6-chloro-N- (3-iodo-4-methyl-phenyl)pyrazine-2-carboxamide (12) was the most active compound in the TAACF antituberculosis screening program (IC90 = 0.819 μg/mL).
- Subjects
ORGANIC synthesis; CHLORIDES; CARBOXYLIC acids; ANILINE; AMIDES; PYRAZINES; MYCOBACTERIUM tuberculosis; TUBERCULOSIS treatment; BIOCHEMISTRY; THERAPEUTICS
- Publication
Molecules, 2009, Vol 14, Issue 10, p4180
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules14104180