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- Title
Immunoregulation of Theiler’s virus-induced demyelinating disease by glatiramer acetate without suppression of antiviral immune responses.
- Authors
Omura, Seiichi; Sato, Fumitaka; Martinez, Nicholas E.; Range, Tierra; Ekshyyan, Lesya; Minagar, Alireza; Alexander, J. Steven; Tsunoda, Ikuo
- Abstract
While most disease-modifying drugs (DMDs) regulate multiple sclerosis (MS) by suppressing inflammation, they can potentially suppress antiviral immunity, causing progressive multifocal leukoencephalopathy (PML). The DMD glatiramer acetate (GA) has been used for MS patients who are at high risk of PML. We investigated whether GA is safe for use in viral infections by using a model of MS induced by infection with Theiler’s murine encephalomyelitis virus (TMEV). Treatment of TMEV-infected mice with GA neither enhanced viral loads nor suppressed antiviral immune responses, while it resulted in an increase in the <italic>Foxp3</italic>/<italic>Il17a</italic> ratio and IL-4/IL-10 production. This is the first study to suggest that GA could be safe for MS patients with a proven viral infection.
- Subjects
THEILERIOSIS; IMMUNOREGULATION; GLATIRAMER acetate; ANTIVIRAL agents; VIRAL disease treatment; DEMYELINATION
- Publication
Archives of Virology, 2018, Vol 163, Issue 5, p1279
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-018-3729-6