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- Title
Analysis of Electrophysiological Mechanisms of N-Deacetyllapaconitine Monochlorhydrate, the Main Metabolite of Lappaconitine Hydrobromide.
- Authors
Tsorin, I. B.; Teplov, I. Yu.; Zinchenko, V. P.; Vititnova, M. B.; Tsyrlina, E. M.; Yunusov, M. S.; Kryzhanovskii, S. A.
- Abstract
In in vitro experiments on isolated rat hippocampal neurons, we studied the electrophysiological mechanisms of the antiarrhythmic effects of N-deacetyllappaconitine monochlorhydrate (DALCh), active metabolite of lappaconitine hydrobromide (allapinin). Electrical activity of neurons was recorded by the patch-clamp method in the whole cell configuration. It was shown that DALCh increased the duration of both slow and fast depolarization phases and decreased the amplitude of the action potential. DALCh effectively inhibited transmembrane currents of Na+ ions and partially K+ ions through the corresponding transmembrane voltage-gated ion channels. Thus, DALCh, in contrast to lappaconitine hydrobromide, belongs not to 1C, but to the 1A class of antiarrhythmics according to the Vaughan-Williams classification.
- Subjects
ION channels; VOLTAGE-gated ion channels; ELECTROPHYSIOLOGY; ACTION potentials
- Publication
Bulletin of Experimental Biology & Medicine, 2022, Vol 173, Issue 2, p219
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-022-05522-2