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- Title
Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction.
- Authors
Han, Sang Won; Song, Tae Jin; Bushnell, Cheryl D.; Lee, Sung‐Soo; Kim, Seo Hyun; Lee, Jun Hong; Kim, Gyu Sik; Kim, Ok‐Joon; Koh, Im‐Seok; Lee, Jong Yun; Suk, Seung‐Han; Lee, Sung Ik; Nam, Hyo Suk; Lee, Kyung‐Yul; Park, Jae Hyeon
- Abstract
<bold>Background and Purpose: </bold>The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse) study showed a significant decrease in transcranial Doppler pulsatility index (PI) with cilostazol treatment after 90 days of acute lacunar infarction. The aim of this analysis was to perform a subgroup analysis of the ECLIPse study to explore the relationship between serum uric acid (UA) and the volume of white matter hyperintensities (WMH) in patients with acute lacunar infarction.<bold>Methods: </bold>The ECLIPse was a multicenter, randomized, double-blind, placebo-controlled study conducted in Korea. For this subgroup analysis, WMH volume was measured for those subjects for whom FLAIR or T2-weighted images were available using semiautomated computerized software.<bold>Results: </bold>Of the 203 patients in 8 hospitals in the ECLIPse study, 130 in 6 hospitals were entered for this subgroup analysis. The mean age was 64.7 ± 9.95 years, and 20.8% were women. The mean WMH volume was 11.57 cm(3) (.13 to 68.45, median 4.86) and mean serum UA was 5.2 mg/dL (1.5 to 8.9). Multiple linear regression analysis revealed that age (P < .001) and serum UA (P = .013) were significantly associated with WMH volume. Age-adjusted scatterplots showed that serum UA level was positively related to WMH volume in patients with acute lacunar infarction (r = 0.275, P = .003).<bold>Conclusions: </bold>This study showed that serum UA was associated with cerebral WMH in patients with acute lacunar infarction.
- Subjects
URIC acid; LEUKOENCEPHALOPATHIES; LACUNAR stroke; TRANSCRANIAL Doppler ultrasonography; RANDOMIZED controlled trials; HETEROCYCLIC compounds; BRAIN; COMPARATIVE studies; LONGITUDINAL method; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; PHYSICS; RESEARCH; STATISTICS; EVALUATION research; BLIND experiment
- Publication
Journal of Neuroimaging, 2016, Vol 26, Issue 3, p351
- ISSN
1051-2284
- Publication type
journal article
- DOI
10.1111/jon.12308