We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Metabolite Alteration in Basal Ganglia Associated with Psychiatric Symptoms of Abstient Toluene Users: A Proton MRS Study.
- Authors
Takebayashi, Kiyokazu; Sekine, Yoshimoto; Takei, Nori; Minabe, Yoshio; Isoda, Haruo; Takeda, Hiroyasu; Nishimura, Katsuhiko; Nakamura, Kazuhiko; Suzuki, Katsuaki; Iwata, Yasuhide; Sakahara, Harumi; Mori, Norio
- Abstract
Long-term toluene abuse causes a variety of psychiatric symptoms. However, little is known about abnormalities at the neurochemical level in the living human brain after long-term exposure to toluene. To detect neurochemical changes in the basal ganglia of subjects with a history of long-term toluene use, proton magnetic resonance spectroscopy (1H MRS) was performed in 12 abstinent toluene users and 13 healthy comparisons with no history of drug abuse. N-acetylaspartate (NAA), creatine plus phosphocreatine (Cr+ PCr), cholinecontaining compounds (Cho), and myo-inositol (MI) levels were measured in the left: and right basal ganglia. The Cho/Cr+ PCr ratio, a marker of membrane metabolism, was significantly increased in the basal ganglia of toluene users in comparison to that of the control subjects. Furthermore, the increase in the Cho/Cr+ PCr ratio was significantly correlated with the severity of residual psychiatric symptoms. These findings suggest that long-term toluene use causes membrane disturbance in the basal ganglia, which is associated with residual psychiatric symptoms that persist even after long-term abstinence from toluene use.
- Subjects
TOLUENE; SYMPTOMS; DRUG abuse; BASAL ganglia; INOSITOL; PROTON magnetic resonance spectroscopy
- Publication
Neuropsychopharmacology, 2004, Vol 29, Issue 5, p1019
- ISSN
0893-133X
- Publication type
Article
- DOI
10.1038/sj.npp.1300426