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- Title
Myosin V motor proteins: marching stepwise towards a mechanism.
- Authors
Vale, Ronald D.
- Abstract
Mammalian myosin V motors transport cargo processively along actin filaments. Recent biophysical and structural studies have led to a detailed understanding of the mechanism of myosin V, making it perhaps the best understood cytoskeletal motor. In addition to describing the mechanism, this review will illustrate how "dynamic" single molecule measurements can synergize with "static" protein structural studies to produce amazingly clear information on the workings of a nanometer-scale machine.
- Subjects
MYOSIN; CYTOSKELETON; CYTOLOGY; MOLECULAR pharmacology
- Publication
Journal of Cell Biology, 2003, Vol 163, Issue 3, p445
- ISSN
0021-9525
- Publication type
Article
- DOI
10.1083/jcb.200308093