We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Bis-Thiourea Quaternary Ammonium Salts as Potential Agents against Bacterial Strains from Food and Environmental Matrices.
- Authors
Bonomo, Maria Grazia; Giura, Teresa; Salzano, Giovanni; Longo, Pasquale; Mariconda, Annaluisa; Catalano, Alessia; Iacopetta, Domenico; Ceramella, Jessica; Sinicropi, Maria Stefania; Saturnino, Carmela
- Abstract
In recent years, the phenomenon of antibiotic resistance in hospitals, communities and the environment has increasingly grown, so antibiotic resistance has become an urgent problem that requires a decisive and global intervention. Incorrect/unnecessary use of antibiotics contributes to increase the ability of microorganisms to develop resistance faster and faster. Research efforts must, therefore, be made to ensure a future in which antibiotic drugs will still be useful in combating infectious diseases. The search for new antibacterial compounds is fundamental. In this study, the antimicrobial activity of the compounds was evaluated against selected bacterial strains from food and environmental matrices by using the Agar Well Diffusion Assay. A total of thirty-six Gram-positive and Gram-negative bacteria were employed to determine the action spectrum and the antimicrobial effectiveness of a small series of thiourea derivatives. Results showed that the highest activities were found for compounds 1 and 4. The important role of the alkyl chain length and/or guanidine moiety in the width of action spectrum was evidenced. Further studies will allow evaluating the efficacy of the inhibiting action and the molecular mechanisms underlying this activity in order to identify compounds capable of counteracting the phenomenon of antibiotic resistance and to identify possible future applications of these newly synthesized compounds that have shown a high bactericidal action potential.
- Subjects
QUATERNARY ammonium salts; THIOUREA; ACTION spectrum; BACTERICIDAL action; DRUG resistance in bacteria
- Publication
Antibiotics (2079-6382), 2021, Vol 10, Issue 12, p1466
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics10121466