We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Humoral and Cellular Vaccination Responses against SARS-CoV-2 in Hematopoietic Stem Cell Transplant Recipients.
- Authors
Lindemann, Monika; Klisanin, Vesna; Thümmler, Laura; Fisenkci, Neslinur; Tsachakis-Mück, Nikolaos; Ditschkowski, Markus; Schwarzkopf, Sina; Klump, Hannes; Reinhardt, Hans Christian; Horn, Peter A.; Koldehoff, Michael
- Abstract
The cellular response to SARS-CoV-2 vaccination and infection in allogeneic hematopoietic stem cell transplant (HSCT) recipients is not yet clear. In the current study, HSCT recipients prior to and post vaccination were tested for SARS-CoV-2-specific humoral and cellular immunity. Antibodies against spike (S) 1 were assessed by Anti-SARS-CoV-2 IgG ELISA (Euroimmun). Cellular immunity was analyzed by an in house interferon-gamma ELISpot and T-SPOT.COVID (Oxford Immunotec), using altogether seven SARS-CoV-2-specific antigens. In 117 HSCT patients vaccinated twice, SARS-CoV-2 IgG antibodies were significantly higher than in HSCT controls pre vaccination (p < 0.0001). After the second vaccination, we observed a median antibody ratio of 4.7 and 68% positive results, whereas 35 healthy controls reached a median ratio of 9.0 and 100% positivity. ELISpot responses in patients were significantly (p < 0.001) reduced to ≤33% of the controls. After the second vaccination, female HSCT patients and female healthy controls showed significantly higher antibody responses than males (6.0 vs. 2.1 and 9.2 vs. 8.2, respectively; p < 0.05). Cellular immunity was diminished in patients irrespective of sex. In conclusion, especially male HSCT recipients showed impaired antibody responses after SARS-CoV-2 vaccination. Changing the vaccine schedule or composition could help increase vaccine responses.
- Subjects
CELLULAR immunity; STEM cell transplantation; HEMATOPOIETIC stem cells; SARS-CoV-2; VACCINE effectiveness; VACCINATION
- Publication
Vaccines, 2021, Vol 9, Issue 10, p1075
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines9101075